Invitrogen™ Cdc6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA577901

Catalog No. PIPA577901

Description

Positive Control: Jurkat, HeLa, HeLa (10 mM Hydroxyurea treatment for 18 hr), Neuro2A, GL261, C8D30, BCL-1, Raw264.7, C2C12, PC-12, Rat2 Predicted Reactivity: Bovine (89%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

Specifications

• Antigen: Cdc6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDC6
• Gene Alias: CDC18(S.pombe); CDC18L; cdc18-related protein; CDC6; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6; cell division cycle 6 homolog; HsCDC18; HsCDC6; p62(cdc6)
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23834, 360621, 990
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.36 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O89033, Q99741
• Gene Symbols: CDC6
• Immunogen: Recombinant protein encompassing a sequence within the center region of human CDC6. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG