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Description
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq]
Specifications
Specifications
| Antigen | CDC6 |
| Applications | Immunofluorescence, Immunohistochemistry (PFA fixed) |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | CDC6 polyclonal antibody raised against recombinant human CDC6. |
| Dilution | Immunofluorescence (1-4 ug/mL) Immunohistochemistry (1:10-1:20) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide) |
| Gene Alias | CDC18L/HsCDC18/HsCDC6 |
| Gene Symbols | CDC6 |
| Host Species | Rabbit |
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