Invitrogen™ CDC7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109501

Catalog No. PIPA5109501

Description

Immunogen sequence: EGSVGLSVQR SVFGERNFNI HSSISHESPA VKLMKQSKTV DVLSRKLATK KKAISTKVMN SAVMRKTASS CPASLTCDCY ATDKVCSICL SRRQQVAPRA GTPGFRAPEV LTKCPNQTTA IDMWSAGVIF LSLLSGRYPF YKASDDLTAL AQIMTIRGSR ETIQAAKTFG KSILCSKEVP AQDLRKLCER LRGMDSSTPK LTSDIQGHAS HQPAISEKTD HKASCLVQTP PGQYSGNSFK KGDSNSCEHC FDEYNTNLEG WNEVPDEAYD LLDKLLDLNP ASRITAEEAL LHPFFKDMSL.

CDC7 is a cell division cycle 7 homolog protein that is critical for the G1/S transition and is also essential for initiation of DNA replication as cell division occurs. CDC7 is expressed in many normal tissues, but the overexpression of CDC7 may be associated with neoplastic transformation for some tumors and transformed cell lines. CDC7/DBF4 kinase promotes S phase by alleviating an inhibitory activity in Mcm4 that evolved to integrate several protein kinase. CDC7 encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.

Specifications

• Antigen: CDC7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDC7
• Gene Alias: AI597260; Cdc7; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; Cdc7 Kinase; Cdc7l1; CDC7-like 1; CDC7-related kinase; cell division cycle 7; cell division cycle 7 (S. cerevisiae); cell division cycle 7 homolog; cell division cycle 7-like 1; cell division cycle 7-like protein 1; cell division cycle 7-related protein kinase; HsCDC7; Hsk1; huCDC7; MGC117361; MGC126237; MGC126238; MGC91067; muCdc7
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8317
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00311
• Gene Symbols: CDC7
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 275-574 of human CDC7 (NP_001127892.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG