Invitrogen™ Cdc73 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529114

Catalog No. PIPA529114

Description

Recommended positive controls: 293T, A431, H1299, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (100%), Rat (99%), Zebrafish (90%), Xenopus laevis (91%), Dog (100%), Chicken (97%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.

Specifications

• Antigen: Cdc73
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDC73
• Gene Alias: 8430414L16Rik; BC027756; C130030P16Rik; C1orf28; C81219; Cdc73; cell division cycle 73; cell division cycle 73 Paf1/RNA polymerase II complex component-like protein; cell division cycle 73, Paf1/RNA polymerase II complex component; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; FIHP; HPTJT; HRPT1; HRPT2; hyperparathyroidism 2 (with jaw tumor); hyperparathyroidism 2 homolog; hyperparathyroidism 2 protein; Hyperparathyroidism 2 protein homolog; HYX; Paf1/RNA polymerase II complex component; parafibromin; Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79577
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.89 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q6P1J9
• Gene Symbols: CDC73
• Immunogen: Recombinant fragment corresponding to a region within amino acids 74 and 346 of Human Parafibromin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov