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CDH1 Mouse anti-Canine, Human, Clone: OTI1F3, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF800671

Encompass_Preferred

Catalog No. 50-166-5247


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintece of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
Specifications

Specifications

CDH1
Monoclonal
Unconjugated
CDH1
Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO
Mouse
Affinity Chromatography
RUO
442858, 999
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunohistochemistry (Paraffin), Western Blot
OTI1F3
PBS with 8% trehalose and no preservative; pH 7.3
F1PAA9, P12830
CDH1
Full length human recombit protein of human CDH1 produced in HEK293T cell.
100 μg
Primary
Canine, Human
Antibody
IgG1
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