Invitrogen™ CDH4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587984

Catalog No. PIPA587984

Description

Immunogen sequence: KRREKERHTK QLLIDPEDDV RDNILKYDEE GGGEEDQDYD LSQLQQPEAM GHVPSKAPGV RRVDERPVGA EPQYPIRPMV PHPGDIGDFI NEGLRAADND PTAPPYDSLL VFDYEGSGST AGSVSSLNSS SSGDQDYDYL NDWGPRFKKL ADMYGGGEED; Positive Samples: HepG2, Mouse brain, Mouse thymus, Rat brain, Rat skeletal muscle; Cellular Location: Cell membrane, Single-pass type I membrane protein.

CDH4 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CDH4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cdh4
• Gene Alias: AW120700; CAD4; Cadherin; cadherin 4; cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin-4; Cdh4; Cdh4l; Rcad; R-CAD; R-Cadh; R-cadherin; retina cadherin; retinal cadherin
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1002, 114588, 12561
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.44 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P39038, P55283, Q63149
• Gene Symbols: Cdh4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 757-916 of human CDH4 (NP_0017852).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG