Invitrogen™ CDH4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578376

Catalog No. PIPA578376

Description

Predicted Reactivity: Human (100%), Chicken (91%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CDH4 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CDH4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cdh4
• Gene Alias: AW120700; CAD4; Cadherin; cadherin 4; cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin-4; Cdh4; Cdh4l; Rcad; R-CAD; R-Cadh; R-cadherin; retina cadherin; retinal cadherin
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1002, 12561
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P39038, P55283
• Gene Symbols: Cdh4
• Immunogen: Recombinant protein encompassing a sequence within the center region of human R-cadherin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG