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Invitrogen™ CDIP1 Polyclonal Antibody
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Catalog No. PIPA561940
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100 μL
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PIPA561940 100 μL
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Catalog No. PIPA561940 Supplier Invitrogen™ Supplier No. PA561940
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CLINDFKDVT HTCPSCKAYI YTYKLLC Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDIP1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CDIP1
Gene Accession No. Q9H305
Gene Alias 2700048O17Rik; 5730403B10Rik; AU018521; AW742692; C16orf5; CDIP; CDIP1; cell death inducing protein; cell death inducing Trp53 target 1; cell death involved p53-target; cell death-inducing p53 target 1; cell death-inducing p53-target protein 1; Cell death-inducing protein; I1; Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein; LITAFL; LITAF-like protein; Transmembrane protein I1
Gene Symbols CDIP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CDIP1. Recombinant protein control fragment (Product #RP-101138).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29965
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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