CDK1 Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA596129	100 μL

Catalog No. PIPA596129 Supplier Thermo Scientific Supplier No. PA596129

Description

Rabbit Polyclonal Antibody

Positive Samples: HL-60, HeLa, THP-1, Rat spleen; Cellular Location: Cytoplasm, Mitochondrion, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle Immunogen sequence: ATKKPLFHGD SEIDQLFRIF RALGTPNNEV WPEVESLQDY KNTFPKWKPG SLASHVKNLD ENGLDLLSKM LIYDPAKRIS GKMALNHPYF NDLDNQIKKM

CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

Specifications

• Antigen: CDK1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.95 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene: CDK1
• Gene Accession No.: P06493, P11440, P39951
• Gene Alias: 5363, ABL1, cdc, CDC2, cdc-2, cdc2 kinase, CDC28A, Cdc2a, cdc2-a, cdc2Dm, cdc2x1.1, CDCDm, CDK1, Cdk-1, cdk1.S, CDK1/CDC2, CDK1-A, cdk1-b, Cdk1-PA, CDKN1, cell cycle controller CDC2, cell cycle p34 CDC2 kinase protein, cell division control, cell division control protein 2 homolog, Cell division control protein 2 homolog 1, cell division control protein 2-A, cell division cycle 2 homolog A, cell division cycle 2 like, cell division cycle 2, G1 to S and G2 to M, Cell division cycle control protein 2, cell division cycle control protein 2a, cell division protein kinase 1, Cell division protein kinase 1-A, CG5363, CG5363-PA, cyclin dependent kinase, cyclin dependent kinase 1, cyclin-dependent kinase, Cyclin-dependent kinase 1, cyclin-dependent kinase 1 S homeolog, cyclin-dependent kinase 1-A, D2366, Dcdc2, dCdk1, DKFZp686L20222, Dm cdc2, Dmcdc2, DmCdk1, Dmel\CG5363, Dmel_CG5363, DNA polymerase delta catalytic subunit, DNA polymerase III, DNA-directed DNA polymerase delta POL3, group 4, HPR6, KCIP-1, l(2)31Eh, LD38718p, maturation-promoting factor, MGC111195, MGC53829, MPF, OTTHUMP00000019660, P34 CDK1, P34 MGC111195, p34 protein kinase, p34 protein kinase 1, p34<CDC2>, p34cdc2, p34-cdc2 homologue, POL3, Protein 1054, protein 2, PSTAIR, TEX1, unnamed protein product, xcdc2, XELAEV_18036802mg, YDL102W
• Gene Symbols: CDK1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 198-297 of human CDK1 (NP_0017771)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12534, 54237, 983
• Target Species: Human, Mouse, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov