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Invitrogen™ CDK12 Polyclonal Antibody
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Catalog No. PIPA582330
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100 μL
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PIPA582330 100 μL
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Catalog No. PIPA582330 Supplier Invitrogen™ Supplier No. PA582330
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GFSAIDTDER NSGPALTESL VQTLVKNRTF SGSLSHLGES SSYQGTGSVQ FPGDQDLRFA RVPLALHPVV GQPFLKAEGS SNSVVHAETK LQNYGELGPG TTGASSSGAG LHWGGPTQSS AY Highest antigen sequence indentity to the following orthologs: Mouse - 85%, Rat - 87%.

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK12
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CDK12
Gene Accession No. Q9NYV4
Gene Alias 1810022J16Rik; AI646528; CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; Cdk12; Cell division cycle 2-related protein kinase 7; cell division protein kinase 12; CRK7; CRKR; Crkrs; cyclin dependent kinase 12; cyclin-dependent kinase 12; cyclin-dependent kinase 12 isoform; D11Ertd752e; H KIAA0904; hCDK12; Kiaa0904; Pksc; Protein kinase for splicing component
Gene Symbols CDK12
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CDK12. Recombinant protein control fragment (Product #RP-89808).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51755
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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