Invitrogen™ CDK2AP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566098

Catalog No. PIPA566098

Description

Immunogen sequence: ATSSQYRQLLS DYGPPSLGYT QGTGNSQVPQ SKYAELLAII EELGKEI Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Specifications

• Antigen: CDK2AP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDK2AP1
• Gene Alias: Apc10; CDK2 (cyclin-dependent kinase 2)-associated protein 1; Cdk2ap1; CDK2-associated protein 1; CDKAP1; cyclin dependent kinase 2 associated protein 1; cyclin-dependent kinase 2 associated protein 1; cyclin-dependent kinase 2-associated protein 1; Deleted in oral cancer 1; Deleted in oral cancer-1; Doc1; doc-1; DORC1; p12; p12DOC-1; Putative oral cancer suppressor; ST19
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8099
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O14519
• Gene Symbols: CDK2AP1
• Immunogen: Recombinant Human CDK2AP1. Recombinant protein control fragment (Product #RP-106793).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG