CDK2AP1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8456	Proteintech Group Inc 130602AP150UL	150 μL

Description

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Specifications

• Antigen: CDK2AP1
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O14519
• Gene ID (Entrez): 8099
• Immunogen: CDK2AP1 Fusion Protein Ag3736
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CDK2AP1

• Concentration: 0.17 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CDK2 associated protein 1, CDK2AP1, CDKAP1, Deleted in oral cancer 1, doc 1, DOC1, DORC1, p12DOC 1, ST19
• Gene Symbols: CDK2AP1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody