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CDK4 Monoclonal Antibody (DCS-35), Biotin, Invitrogen™

Catalog No. PIMA512981
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500 μL
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Catalog No. Quantity
PIMA512981 500 μL
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Catalog No. PIMA512981 Supplier Thermo Scientific Supplier No. MA512981

Description

Mouse Monoclonal Antibody

MA5-12981 targets Cdk4 in IF, IP, and WB applications and shows reactivity with Human, mouse, Porcine, and Rat samples. The MA5-12981 immunogen is purified recombinant cdk4 protein.

CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK4
Applications Immunocytochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone DCS-35
Concentration 0.2 mg/mL
Conjugate Biotin
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Cdk4
Gene Accession No. P11802, P30285, P35426, P79432
Gene Alias Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34<PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)
Gene Symbols Cdk4
Host Species Mouse
Immunogen Purified recombinant cdk4 protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100144492, 1019, 12567, 94201
Target Species Human, Mouse, Pig, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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