CDK4Rabbit anti-Human, Mouse, Rat, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-0031	100 μL

Catalog No. 50-199-0031 Supplier Rockland Immunochemicals Supplier No. 100401162

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Antiserum will specifically react with a 34 kDa cdk4 (p34) protein from human, rat and mouse tissue. No reaction was observed against other related cyclin dependent kinases. Cross reactivity with cdk4 (p34) from other species has not been determined.

CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.

Specifications

• Antigen: CDK4
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 85 mg/mL
• Conjugate: Unconjugated
• Formulation: Antibody with 0.01% sodium azide; pH
• Gene: Cdk4
• Gene Accession No.: P11802, P30285, P35426
• Gene Alias: BOS_5594; CDK4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; Cyclin-dependent kinase 4; MGC14458; p34/cdk4; PSK-J3; serine/threonine kinase
• Gene Symbols: Cdk4
• Host Species: Rabbit
• Immunogen: CDK4 (p34) peptide corresponding to the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1019, 12567, 94201
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid