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Invitrogen™ CDK5 Monoclonal Antibody (1H3)
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Catalog No. PIMA547686
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100 μL
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PIMA547686 100 μL
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Catalog No. PIMA547686 Supplier Invitrogen™ Supplier No. MA547686
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Description

Mouse Monoclonal Antibody

Specific for endogenous levels of the ~28 kDa Cdk5 protein. Shows no cross reactivity with the Cdk5 cofactor p35 or its degradation product p25.

CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK5
Applications Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 1H3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 10mM HEPES with 100μg/mL BSA, 50% glycerol, 150mM NaCl and no preservative; pH 7.5
Gene CDK5
Gene Accession No. P49615, Q00535, Q03114
Gene Alias AW048668; Cdk5; CDK5 activator 1; CDK5-SV; CDKN5; Cell division protein kinase 5; CR6 protein kinase; Crk6; cyclin dependent kinase 5; cyclin-dependent kinase 5; cyclin-dependent-like kinase 5; LIS7; protein kinase CDK5 splicing; PSSALRE; Serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Symbols CDK5
Host Species Mouse
Immunogen Purified rat Cdk5.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1020, 12568, 140908
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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