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Tocris Bioscience™ CDK8/19i
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Catalog No. 737250
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Catalog No. Quantity
73-725-0 50 mg
73-721-0 10 mg
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Catalog No. 73-725-0 Supplier Tocris Bioscience™ Supplier No. 7372/50
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Description

Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture

CDK8/19i is a potent and selective CDK8 and CDK19 inhibitor (IC50 values are 2.9 and 14.1 nM, respectively). CDK8/19i maintains pluripotency of mouse PSCs in culture. It induces the formation of dome-shaped colonies and upregulates Nanog-GFP reporter and endogenous Nanog expression in mouse ESCs in vitro.

Specifications

Chemical Name or Material N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
CAS 923596-52-5
Quantity 50 mg
Target Cyclin-dependent Kinase Inhibitors
Molecular Formula C14H15N5
Purity 0.98
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