Invitrogen™ CDK9 Monoclonal Antibody (1B5D10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515850

Catalog No. PIMA515850

Description

MA5-15850 targets CDK9 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-15850 immunogen is purified recombinant fragment of human CDK9 expressed in E. Coli. . MA5-15850 detects CDK9 which has a predicted molecular weight of approximately 43kDa.

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.

Specifications

• Antigen: CDK9
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: P50750
• Gene Symbols: CDK9
• Immunogen: Purified recombinant fragment of human CDK9 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 1025
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 1B5D10
• Conjugate: Unconjugated
• Gene: CDK9
• Gene Alias: C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1