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CDK9 Polyclonal Antibody, Active Motif™
SDP

Rabbit Polyclonal Antibody

$156.65 - $620.58

Specifications

Antigen CDK9
Concentration Lot-Specific
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3497
SDP
Encompass
View Documents
Active Motif
61560
10 μL
Each for $156.65
Only null left
Add to Cart
 
50-199-3496
SDP
Encompass
View Documents
Active Motif
61559
100 μL
Each for $620.58
Only null left
Add to Cart
 
Description

Description

CDK9 (cyclin-dependent kinase 9) is a member of the cyclin-dependent protein kinase family. It is involved in the regulation of transcription. CDK9 is a member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex. This complex facilitates the transition from abortive to productive elongation by phosphorylating the CTD of the large subunit of RNA polymerase II, POLR2A, SUPT5H, and RDBP. The complex is inactive when in the 7SK snRNP complex form. CDK9 phosphorylates EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELF. It regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
Specifications

Specifications

CDK9
Western Blot
Unconjugated
Rabbit
Human
P50750
1025
This antibody was raised against a peptide within the N-terminal region of human CDk9.
Primary
-20°C, Avoid Freeze/Thaw Cycles
CDK9
Lot-Specific
Polyclonal
Liquid
RUO
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
BOS_12097; C-2K; CDC2L4; CDC2-related kinase; CDK9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; Cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
CDK9
IgG
Antigen affinity chromatography
Antibody
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