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CDK9 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA519674
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200 μL
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PIPA519674 200 μL
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Catalog No. PIPA519674 Supplier Thermo Scientific Supplier No. PA519674

Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse, rat, chicken and cow based on sequence homology.

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDK9
Applications Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gene CDK9
Gene Accession No. P50750, Q99J95
Gene Alias C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Gene Symbols CDK9
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human Cdk9.
Purification Method Antigen affinity chromatography
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1025, 107951
Target Species Human, Mouse, X. laevis
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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