Invitrogen™ CDKL2 Monoclonal Antibody (OTI5D9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526749

Catalog No. PIMA526749

Description

CDKL2 Monoclonal Antibody for Western Blot, IHC (P)

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.

Specifications

• Antigen: CDKL2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q92772
• Gene Symbols: CDKL2
• Immunogen: Human recombinant protein fragment corresponding to amino acids 291-493 of CDKL2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5D9
• Conjugate: Unconjugated
• Gene: CDKL2
• Gene Alias: 5330436L21Rik; AI505225; CDC2-related kinase; Cdkl2; cyclin dependent kinase like 2; cyclin-dependent kinase-like 2; cyclin-dependent kinase-like 2 (CDC2-related kinase); Kkiamre; Kkm; P56; p56 KKIAMRE protein kinase; protein kinase p56 KKIAMRE; serine/threonine protein kinase KKIAMRE; serine/threonine-protein kinase KKIAMRE; testicular tissue protein Li 35
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8999
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid