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Invitrogen™ CDKL2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA536209
Description
This antibody detects endogenous protein at a molecular weight of 56 kDa. Purity is >95% by SDS-PAGE.
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
Specifications
CDKL2 | |
Polyclonal | |
Unconjugated | |
CDKL2 | |
5330436L21Rik; AI505225; CDC2-related kinase; Cdkl2; cyclin dependent kinase like 2; cyclin-dependent kinase-like 2; cyclin-dependent kinase-like 2 (CDC2-related kinase); Kkiamre; Kkm; P56; p56 KKIAMRE protein kinase; protein kinase p56 KKIAMRE; serine/threonine protein kinase KKIAMRE; serine/threonine-protein kinase KKIAMRE; testicular tissue protein Li 35 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
305242, 53886, 8999 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 0.05% sodium azide; pH 7.2 | |
Q5XIT0, Q92772, Q9QUK0 | |
CDKL2 | |
Synthetic peptide corresponding to amino acids 210-260 of human KKIAMRE. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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