Invitrogen™ CDKL5 Monoclonal Antibody (CL4888)

Catalog No.	Quantity
PIMA531407	100 μL

Catalog No. PIMA531407 Supplier Invitrogen™ Supplier No. MA531407

Description

Mouse Monoclonal Antibody

Immunogen sequence: AARANSLQLL SPQPGEQLPP EMTVARSSVK ETSREGTSSF HTRQKSEGGV YHDPHSDDGT APKENRHLYN DPVPRRVGSF YRVPSPRPDN SFHENNVSTR VSSLPSESSS GTNHSKRQPA FDP Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 97%.

CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.

Specifications

• Antigen: CDKL5
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: CL4888
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: CDKL5
• Gene Accession No.: O76039
• Gene Alias: BC038161; Cdkl5; CFAP247; cyclin dependent kinase 5 transcript; cyclin dependent kinase like 5; cyclin-dependent kinase-like 5; EIEE2; ISSX; RP1-245G19.3; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9
• Gene Symbols: CDKL5
• Host Species: Mouse
• Immunogen: Recombinant protein fragment of Human CDKL5 (Product #RP-92159)
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6792
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1