Invitrogen™ CDKL5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103286

Catalog No. PIPA5103286

Description

Antibody detects endogenous levels of total CDKL5.

CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.

Specifications

• Antigen: CDKL5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDKL5
• Gene Alias: BC038161; Cdkl5; CFAP247; cyclin dependent kinase 5 transcript; cyclin dependent kinase like 5; cyclin-dependent kinase-like 5; EIEE2; ISSX; RP1-245G19.3; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 382253, 6792
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O76039, Q3UTQ8
• Gene Symbols: CDKL5
• Immunogen: A synthesized peptide derived from human CDKL5(Accession O76039), corresponding to amino acid residues E666-Y716.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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