CDKL5 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1456	100 μL

Catalog No. 50-198-1456 Supplier Bioss Supplier No. BS11538R

Description

Rabbit Polyclonal Antibody

Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.

Specifications

• Antigen: CDKL5
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: CDKL5
• Gene Accession No.: O76039
• Gene Alias: BC038161; CDKL5; CFAP247; cyclin dependent kinase 5 transcript; cyclin dependent kinase like 5; Cyclin-dependent kinase-like 5; EIEE2; ISSX; RP1-245G19.3; serine/threonine kinase 9; Serine/threonine-protein kinase 9; STK9
• Gene Symbols: CDKL5
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human CDKL5.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6792
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG