CDKN1A Mouse anti-Human, Clone: HJ21, Abnova™
Mouse monoclonal antibody raised against full length recombinant human CDKN1A.
Manufacturer: Abnova Corporation MAB13244
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]
|Mouse monoclonal antibody raised against full length recombinant human CDKN1A.|
|In 10mM PBS.|
|Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
|This monoclonal antibody is highly specific to CDKN1A and shows no cross-reaction with other closely related mitotic inhibitors.|
|Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)|
|Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.|
|Recombinant protein corresponding to full length human CDKN1A.|
|Protein A/G purification|
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