CDKN1A Mouse anti-Human, Clone: OTI2D3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF808505

Catalog No. 50-166-8895

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.

Specifications

• Antigen: CDKN1A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CDKN1A
• Gene Alias: CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1026
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2D3
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P38936
• Gene Symbols: CDKN1A
• Immunogen: Human recombit protein fragment corresponding to amino acids 2-164 of human CDKN1A produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1