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Description
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq]
Specifications
Specifications
| Antigen | CDKN1B |
| Applications | Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Monoclonal |
| Clone | KIP1/769 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against full length recombinant human CDKN1B. |
| Dilution | Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d |
| Formulation | In 10mM PBS. |
| Gene Alias | CDKN4/KIP1/MEN1B/MEN4/P27KIP1 |
| Gene Symbols | CDKN1B |
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