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Invitrogen™ CDKN2A (Isoform 3) Polyclonal Antibody
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Catalog No. PIPA5142205
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100 μg
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Catalog No. Quantity
PIPA5142205 100 μg
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Catalog No. PIPA5142205 Supplier Invitrogen™ Supplier No. PA5142205
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Description

Goat Polyclonal Antibody

Additional Information: This antibody is expected to recognize the pancreas isoform (NP_478104.1) only. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDKN2A (Isoform 3)
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene CDKN2A
Gene Accession No. P42771, Q8N726
Gene Symbols CDKN2A
Host Species Goat
Immunogen Peptide with sequence C-ILRKKGRLPGEFSE.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1029
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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