CDKN2A Mouse anti-Human, Clone: 1D7D2A1, Abnova™
Mouse monoclonal antibody raised against partial recombinant human CDKN2A.
Manufacturer: Abnova Corporation MAB12264
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq]
|Mouse monoclonal antibody raised against partial recombinant human CDKN2A.|
|In PBS (0.05% sodium azide)|
|ELISA, Flow Cytometry, Immunohistochemistry (PFA fixed), Western Blot|
|ELISA (1:10000) Flow Cytometry (1:200-1:400) Immunohistochemistry (1:200-1:1000) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.|
|Recombinant protein corresponding to amino acids 1-156 of human CDKN2A.|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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