CDKN2C Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5104235

Catalog No. PIPA5104235

Description

Antibody detects endogenous levels of total p18 INK4c.

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

Specifications

• Antigen: CDKN2C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDKN2C
• Gene Alias: C77269; CDK6 inhibitor p18; Cdkn2c; CDKN6; cyclin dependent kinase inhibitor 2C; cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4c; p18; p18INK4c; p18-INK4c; p18-INK6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1031, 12580
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P42773, Q60772
• Gene Symbols: CDKN2C
• Immunogen: A synthesized peptide derived from human CDKN2C(Accession P42773), corresponding to amino acid residues L122-Q168.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Non-human Primate
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov