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CDNF/ARMETL1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981419
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50-198-1419 100 μL
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Catalog No. 50-198-1419 Supplier Bioss Supplier No. BS11499R
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Description

Rabbit Polyclonal Antibody

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.

Specifications

Antigen CDNF/ARMETL1
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Cdnf
Gene Accession No. Q49AH0
Gene Alias 9330140G23; Arginine-rich protein mutated in early stage tumors-like 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; CDNF; Cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor
Gene Symbols Cdnf
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ARMETL1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 441549
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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