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Invitrogen™ CDw17 Monoclonal Antibody (B392 (HuLy-m13))
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Catalog No. MA191271
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Quantity:
200 μg
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Catalog No. Quantity
MA191271 200 μg
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Catalog No. MA191271 Supplier Invitrogen™ Supplier No. MA191271
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Description

Mouse Monoclonal Antibody

Recommended positive controls: Tonsil, Lymph Node, Granulocytes, Platelets.

CDw17, also known as Lactosylceramide (LacCer) or CD17, is a glycosphingolipid present on the surface of various cell types, including leukocytes, erythrocytes, and endothelial cells. It serves as a significant component of the cell membrane, involved in cell-cell interactions, cell adhesion, and signal transduction. Lactosylceramide is synthesized by the enzyme B-1,4-galactosyltransferase, which adds a galactose molecule to glucosylceramide. It acts as a precursor for more complex glycosphingolipids, playing critical roles in numerous physiological processes and immune responses. CDw17 is implicated in several pathological conditions, including atherosclerosis, cancer, and inflammatory diseases. In cancer, CDw17 acts as a mediator for tumor cell adhesion, invasion, and metastasis, making it a potential target for therapeutic intervention. Additionally, due to its role in the immune system, modulation of Lactosylceramide levels can influence immune cell functions and inflammatory responses.
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Specifications

Antigen CDw17
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone B392 (HuLy-m13)
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Alias alpha 2,3-sialyltransferase V; CD17; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; GM3 synthase; Lactosylceramide; lactosylceramide alpha-2,3-sialyltransferase; SATI; Sialyltransferase 9; sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase); SIAT9; SIATGM3S; ST3 beta-galactoside alpha-2,3-sialyltransferase 5; ST3 beta-galactoside alpha-23-sialyltransferase 5; ST3Gal V; ST3GAL5; ST3GalV; UNQ2510/PRO5998
Host Species Mouse
Immunogen Immunoprecipitated complexes of human detergent PBL lysate and anti-b2m proteins.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgM
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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