Invitrogen™ CDX1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109508

Catalog No. PIPA5109508

Description

Immunogen sequence: MRRSVAAGGG GGSGKTRTKD KYRVVYTDHQ RLELEKEFHY SRYITIRRKS ELAANLGLTE RQVKIWFQNR RAKERKVNKK KQQQQQPPQP PMAHDITATP AGPSLGGLCP SNTSLLATSS PMPVKEEFLP.

CDX1, or caudal type homeobox 1, is a gene encoding a homeodomain transcription factor that plays a significant role in the development and differentiation of intestinal epithelial cells. CDX1 is expressed in the intestinal crypts, where it is integral to the Wnt/B-catenin signaling pathway, crucial for cell proliferation. Interestingly, while CDX1 expression is initially active, its expression is often silenced as colon cancer progresses in humans, suggesting a complex role in tumor biology. The CDX1 protein functions as a transcriptional regulator that influences proliferation and differentiation, expressing early during intestinal development. In mice, it is involved in the development of the posterior embryo and is associated with abnormal differentiation in metaplastic and neoplastic tissues, providing insight into intestinal-type gastric adenocarcinoma progression. CDX1 is related to other vertebrate Cdx genes such as Cdx2 and Cdx4, which are homologues of the Drosophila caudal gene and are also implicated in embryonic development.

Specifications

• Antigen: CDX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDX1
• Gene Alias: caudal type homeo box 1; caudal type homeo box transcription factor 1; caudal type homeobox 1; caudal type homeobox transcription factor 1; caudal-type homeobox protein 1; caudal-type homeobox protein CDX1; Cdx; CDX1; Cdx-1; Homeobox protein CDX-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1044, 12590
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.31 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P18111, P47902
• Gene Symbols: CDX1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 136-265 of human CDX1 (NP_001795.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov