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Invitrogen™ CDX1 Recombinant Rabbit Monoclonal Antibody (8F6T7)
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Catalog No. PIMA542923
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100 μL
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PIMA542923 100 μL
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Catalog No. PIMA542923 Supplier Invitrogen™ Supplier No. MA542923
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: HT-29, SGC-7901. Immunogen sequence: MYVGYVLDKD SPVYPGPARP ASLGLGPQAY GPPAPPPAPP QYPDFSSYSH VEPAPAPPTA WGAPFPAPKD DWAAAYGPGP AAPAASPASL AFGPPPDFSP.

CDX1, or caudal type homeobox 1, is a gene encoding a homeodomain transcription factor that plays a significant role in the development and differentiation of intestinal epithelial cells. CDX1 is expressed in the intestinal crypts, where it is integral to the Wnt/B-catenin signaling pathway, crucial for cell proliferation. Interestingly, while CDX1 expression is initially active, its expression is often silenced as colon cancer progresses in humans, suggesting a complex role in tumor biology. The CDX1 protein functions as a transcriptional regulator that influences proliferation and differentiation, expressing early during intestinal development. In mice, it is involved in the development of the posterior embryo and is associated with abnormal differentiation in metaplastic and neoplastic tissues, providing insight into intestinal-type gastric adenocarcinoma progression. CDX1 is related to other vertebrate Cdx genes such as Cdx2 and Cdx4, which are homologues of the Drosophila caudal gene and are also implicated in embryonic development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDX1
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 8F6T7
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CDX1
Gene Accession No. P47902
Gene Alias caudal type homeo box 1; caudal type homeo box transcription factor 1; caudal type homeobox 1; caudal type homeobox transcription factor 1; caudal-type homeobox protein 1; caudal-type homeobox protein CDX1; Cdx; CDX1; Cdx-1; Homeobox protein CDX-1
Gene Symbols CDX1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cdx1 (P47902).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1044
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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