CEA Mouse anti-Human, Clone: C66/195, Abnova™

Catalog No.	Quantity
89-933-947	100 μg

Catalog No. 89-933-947 Supplier Abnova Corporation Supplier No. MAB13255

Description

Mouse monoclonal antibody raised against full length recombinant human Carcinoembryonic Antigen (CEA).

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined. [provided by RefSeq]

Specifications

• Antigen: CEA
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
• Classification: Monoclonal
• Clone: C66/195
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against full length recombinant human Carcinoembryonic Antigen (CEA).
• Dilution: Flow Cytometry (0.5-1 ug/10⁶ cells in 0.1 mL) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 10mM PBS (0.05% BSA, 0.05% sodium azide).
• Gene Alias: CD66e/CEA/DKFZp781M2392
• Gene Symbols: CEACAM5
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to full length human Carcinoembryonic Antigen.
• Purification Method: Protein A/G purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1048/634
• Test Specificity: This monoclonal antibody reacts with nonspecific cross-reacting antigen (NCA) and shows a cross-reaction with human polymorphonuclear leukocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues.
• Target Species: Human
• Content And Storage: Store at 4°C.
• Form: Liquid
• Isotype: IgG1 κ