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Tocris Bioscience™ Cediranib
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Catalog No. 745410
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74-541-0 10 mg
74-545-0 50 mg
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Description

Potent inhibitor of VEGFR, PDGFR and FGFR

Cediranib is a highly potent and ATP-competitive inhibitor of VEGFR2 (IC50 = <1 nM). Cediranib also potently inhibits PDGFR1, VEGFR3, VEGFR1, c-Kit, PDGFR2 and FGFR1 (IC50 values are 2, 3, 5, 5, 26 and 36 nM, respectively), and inhibits CSF-1R, Src, and Abl (IC50 values are 110, 130 and 260 nM, respectively). Cediranib induces hypoxia, prevents VEGF-induced angiogenesis and suppresses homology-directed DNA repair (HDR) factors BRCA1/2 and RAD51. Cediranib decreases cell motility, proliferation and cell viability. Cediranib is active in vivo.

Specifications

Chemical Name or Material 4-[(4-Fluoro-2-methyl-1 H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline
CAS 288383-20-0
Quantity 10 mg
Target VEGF Receptor Inhibitors
Molecular Formula C25H27FN4O3
Purity 0.98
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