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CENP-B Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501571420
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50-157-1420 10 μL
50-157-1419 100 μL
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Catalog No. 50-157-1420 Supplier Bethyl Laboratories, Inc Supplier No. IHC00064T
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Specifications

Antigen CENP-B
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene CENPB
Gene Accession No. P07199
Gene Alias Centromere protein B, 80kDa
Gene Symbols CENPB
Host Species Rabbit
Immunogen Between 540 and C-term
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1059
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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