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Invitrogen™ CENPB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115008

Catalog No. PIPA5115008


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Description

Description

Antibody detects endogenous levels of total CENPB.

CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CENPB
Polyclonal
Unconjugated
CENPB
CENPB; CENP-B; CENP-B protein; centromere autoantigen B; centromere protein B; centromere protein B, 80kDa; major centromere autoantigen B
Rabbit
Affinity chromatography
RUO
1059, 12616, 362217
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide
P07199, P27790
CENPB
A synthesized peptide derived from human CENPB(Accession P07199), corresponding to amino acid residues N48-I98.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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