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Invitrogen™ CENPB Polyclonal Antibody
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Catalog No. PIPA543753
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PIPA543753 100 μL
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Catalog No. PIPA543753 Supplier Invitrogen™ Supplier No. PA543753
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Description

Rabbit Polyclonal Antibody

Peptide sequence: GGEDSDSDSE EEDDEEEDDE DEDDDDDEED GDEVPVPSFG EAMAYFAMVK Sequence homology: Cow: 83%; Horse: 86%; Human: 100%; Mouse: 93%; Pig: 86%; Rat: 100%; Sheep: 86%; Yeast: 100%; Zebrafish: 75%.

CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CENPB
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene CENPB
Gene Accession No. P07199
Gene Alias CENPB; CENP-B; CENP-B protein; centromere autoantigen B; centromere protein B; centromere protein B, 80kDa; major centromere autoantigen B
Gene Symbols CENPB
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human CENPB (aa 506-555).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1059
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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