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Invitrogen™ CENPE Monoclonal Antibody (1H12)

Mouse Monoclonal Antibody

$566.00 - $979.50

Specifications

Antigen CENPE
Clone 1H12
Concentration 1 mg/mL
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Applications Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
01-675-178
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Invitrogen™
MA15758
100 μL
Each for $979.50
Only null left
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PIMA518025
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Invitrogen™
MA518025
50 μL
Each for $566.00
Only null left
Add to Cart
 
Description

Description

This target has a predicted molecular weight of 312 kDa and is only suitable for Western blot if IP is performed first.

14-3-3 sigma (stratifin, SFN, epithelial cell marker protein 1) is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known mammalian 14-3-3 isoforms epsilon, beta, zeta, gamma, theta, tau and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 sigmais the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to <FONT face=Symbol>g</FONT>-irradiation and other DNA-damaging agents. 14-3-3 sigmais a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of human 14-3-3 sigma are produced by alternative splicing.
Specifications

Specifications

CENPE
1 mg/mL
Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
Unconjugated
Mouse
RUO
PBS with 0.1% sodium azide
Q02224
1062
Recombinant full length CENP-E protein (human) from SP2/0 cells.
Antibody
1H12
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Monoclonal
Liquid
IgG κ
Human
CENPE
312kDa; AU019344; BC049989; C530022J18; Cenpe; CENP-E; centromere autoantigen E; Centromere autoantigen E (312kD); centromere protein E; centromere protein E, 312kDa; centromere-associated protein E; centromeric protein E; KIF10; kinesin 10; kinesin family member 10; kinesin superfamily protein 10; Kinesin-7; Kinesin-related protein CENPE; MCPH13; Motor domain of KIF10; N-7 kinesin; PPP1R61; protein phosphatase 1, regulatory subunit 61
CENPE
Primary
Ion-exchange chromatography
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