CENPO Monoclonal Antibody (OTI7F9), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809481

Catalog No. 50-168-2822

Description

Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.

Specifications

• Antigen: CENPO
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9BU64
• Gene Symbols: CENPO
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-230 of human CENPO produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: OTI7F9
• Conjugate: Unconjugated
• Gene: CENPO
• Gene Alias: CENP-O, ICEN-36, MCM21R
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79172
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid