Invitrogen™ CENPO Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100722

Catalog No. PIPA5100722

Description

Antibody detects endogenous levels of total CENPO.

Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.

Specifications

• Antigen: CENPO
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CENPO
• Gene Alias: 2810429O05Rik; 8430427C03Rik; CENPO; CENP-O; Centromere protein O; centromeric protein O; D12Ertd482e; ICEN36; ICEN-36; Interphase centromere complex protein 36; MCM21R
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 52504, 79172
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8K015, Q9BU64
• Gene Symbols: CENPO
• Immunogen: A synthesized peptide derived from human CENPO(Accession Q9BU64), corresponding to amino acid residues Y183-F233.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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