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CENPO Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988973
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100 μL
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50-198-8973 100 μL
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Catalog No. 50-198-8973 Supplier Bioss Supplier No. BS9305R
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Description

Rabbit Polyclonal Antibody

Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.

Specifications

Antigen CENPO
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene CENPO
Gene Accession No. Q9BU64
Gene Alias 2810429O05Rik; 8430427C03Rik; Cenpo; CENP-O; Centromere protein O; centromeric protein O; D12Ertd482e; ICEN36; ICEN-36; Interphase centromere complex protein 36; MCM21R
Gene Symbols CENPO
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CENPO.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79172
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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