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Tocris Bioscience™ Centrinone B
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Catalog No. 569010
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Quantity:
10 mg
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Catalog No. 56-901-0

Supplier: Tocris Bioscience™ 5690/10

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Description

High affinity and selective PLK4 inhibitor

Centrinone B is a high affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

Specifications

Chemical Name or Material 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine
CAS 1798871-31-4
Synonym LCR 323
Quantity 10 mg
Target Polo-like Kinase Inhibitors
Molecular Formula C27H27F2N7O5S2
Formula Weight 631.67
Purity >98%
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