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Invitrogen™ CEP135 Polyclonal Antibody
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Catalog No. PIPA5101507
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100 μL
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PIPA5101507 100 μL
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Catalog No. PIPA5101507 Supplier Invitrogen™ Supplier No. PA5101507
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CEP135.

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CEP135
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CEP135
Gene Accession No. Q66GS9, Q6P5D4
Gene Alias BC062951; centrosomal protein 135; centrosomal protein 135kDa; centrosomal protein 4; Centrosomal protein of 135 kDa; centrosomal protein of 135 kDa; LOW QUALITY PROTEIN: centrosomal protein of 135 kDa; centrosome protein cep135; Cep135; Cep4; Gm1044; KIAA0635; MCPH8; RGD1310726
Gene Symbols CEP135
Host Species Rabbit
Immunogen A synthesized peptide derived from human CEP135(Accession Q66GS9), corresponding to amino acid residues A1084-S1134.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 381644, 9662
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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