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CEP135 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982102
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100 μL
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50-198-2102 100 μL
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Catalog No. 50-198-2102 Supplier Bioss Supplier No. BS12282R
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Description

Rabbit Polyclonal Antibody

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Specifications

Antigen CEP135
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene CEP135
Gene Accession No. Q66GS9
Gene Alias BC062951; centrosomal protein 135; centrosomal protein 135kDa; Centrosomal protein 4; Centrosomal protein of 135 kDa; centrosome protein cep135; CEP135; CEP4; Gm1044; KIAA0635; MCPH8
Gene Symbols CEP135
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CEP135 .
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9662
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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