Invitrogen™ CEP78 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101512

Catalog No. PIPA5101512

Description

Antibody detects endogenous levels of total CEP78.

This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients.

Specifications

• Antigen: CEP78
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CEP78
• Gene Alias: 5730599I05Rik; C9orf81; centrosomal protein 78; centrosomal protein 78kDa; centrosomal protein of 78 kDa; Cep78; D030027P05; IP63
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 208518, 84131
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q5JTW2, Q6IRU7
• Gene Symbols: CEP78
• Immunogen: A synthesized peptide derived from human CEP78(Accession Q5JTW2), corresponding to amino acid residues V309-A359.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov