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Invitrogen™ Cerebellin 2 Monoclonal Antibody (704323)
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Catalog No. PIMA524324
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100 μg
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Catalog No. Quantity
PIMA524324 100 μg
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Catalog No. PIMA524324 Supplier Invitrogen™ Supplier No. MA524324
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Description

Mouse Monoclonal Antibody

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other's degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cerebellin 2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 704323
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Cbln2
Gene Accession No. Q8IUK8
Gene Alias 6330593N19Rik; A730004O05; Cbln2; cerebellin 2 precursor; cerebellin 2 precursor protein; Cerebellin2; cerebellin-2; Cerebellin-like protein; UNQ1892/PRO4338
Gene Symbols Cbln2
Host Species Mouse
Immunogen CHO-derived recombinant human Cerebellin-2 Arg50-Leu224.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147381
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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