Invitrogen™ Cerebellin 2 Monoclonal Antibody (704323)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524324

Catalog No. PIMA524324

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other's degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.

Specifications

• Antigen: Cerebellin 2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8IUK8
• Gene Symbols: Cbln2
• Immunogen: CHO-derived recombinant human Cerebellin-2 Arg50-Leu224.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: 704323
• Conjugate: Unconjugated
• Gene: Cbln2
• Gene Alias: 6330593N19Rik; A730004O05; Cbln2; cerebellin 2 precursor; cerebellin 2 precursor protein; Cerebellin2; cerebellin-2; Cerebellin-like protein; UNQ1892/PRO4338
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 147381
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized