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Invitrogen™ Cerebellin 2 Polyclonal Antibody
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Catalog No. PIPA5101514
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PIPA5101514 100 μL
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Catalog No. PIPA5101514 Supplier Invitrogen™ Supplier No. PA5101514
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CBLN2.

Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other's degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cerebellin 2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Cbln2
Gene Accession No. P98087, Q8BGU2, Q8IUK8
Gene Alias 6330593N19Rik; A730004O05; Cbln2; cerebellin 2 precursor; cerebellin 2 precursor protein; Cerebellin2; cerebellin-2; Cerebellin-like protein; UNQ1892/PRO4338
Gene Symbols Cbln2
Host Species Rabbit
Immunogen A synthesized peptide derived from human CBLN2(Accession Q8IUK8), corresponding to amino acid residues M1-R50.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12405, 147381, 291388
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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