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Invitrogen™ Cerebral Protein 1 Polyclonal Antibody
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Catalog No. PIPA584351
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100 μL
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PIPA584351 100 μL
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Catalog No. PIPA584351 Supplier Invitrogen™ Supplier No. PA584351
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AWKGSTTNDP PKQSPGSTSP KPPHTLSRKQ WRNRQKNKRR CKNKFQPPQV PDQAPAEAPT EKTEVSPVPR TDSHEARAGA LRARMAQRLD GARFRYLNE Highest antigen sequence indentity to the following orthologs: Rat - 67%, Mouse - 70%.

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cerebral Protein 1
Applications Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Rrp8
Gene Accession No. O43159
Gene Alias 1500003O22Rik; 2900001K19Rik; AW538116; Cerebral protein 1; cerebral protein 1 homolog; HUCE1; hucep1; hucep-1; KIAA0409; NML; Nucleomethylin; RGD1308302; ribosomal RNA processing 8, methyltransferase, homolog (yeast); ribosomal RNA-processing protein 8; Rrp8; RRP-8; RRP8 methyltransferase homolog
Gene Symbols Rrp8
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RRP8. Recombinant protein control fragment (Product #RP-105076).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23378
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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